Significant skeletal discrepancies , where the upper and lower jaws are discrepant in all dimensions require an additional intervention called Distraction Osteogenesis. Severe congenital anomalies, especially those that are syndromic like Treacher Collin Syndrome, Pierre Robin Syndrome, Cruzon Syndrome or even severe Cleft lip and palate can cause massive deficiencies in the skeletal bones of the face even at birth. It is possible to correct these bony deformities at almost any age using the technique of distraction osteogenesis with appropriate ,specialist ,equipments and appliances.